Ireland all-rounder Alex Cusack will miss the One-Day International against England on 3rd September due to a back injury.
He has been rested from domestic action but will still miss the match, which as one of Ireland's most experienced players, comes as a blow to the hosts.
Cusack, 32, helped Ireland beat England during the 2011 World Cup by sharing a sixth-wicket stand of 162 with Kevin O'Brien, of which his share was 47.
Head coach Phil Simmons, while disappointed to be without Cusack for the match, remains in a positive mood.
"It's certainly disappointing for Alex to miss the game as he's an important player for us, particularly in the power-plays.
"However, we have strength in depth now and it'll give one of the other guys a chance to shine. We are blessed with a number of very talented all-rounders so have plenty of cover in that department."
Nevertheless, Cusack is a man who has scored 2,205 runs and taken 141 wickets since first representing Ireland in 2007 so will be hard to replace.
Simmons added that as the countdown to the match continues, excitement is building.
"We've seen just how well the tickets have gone with over 7,000 sold already. It's going to the biggest match ever held in Ireland, and there will be a fantastic atmosphere at the new international venue at Malahide.
"It's my home town and I know just how much of a buzz there is around the place to have the Ashes winners coming here. It'll be a magnificent occasion, and hopefully we'll give the Irish fans another day to remember."
© Cricket World 2013