Henry Davids has replaced Graeme Smith in South Africa's squad for the third and final One-Day International against Pakistan at Centurion.
Smith has been given compassionate leave following the death of his grandmother earlier this week.
Titans batsman Davids has played nine Twenty20 Internationals but is yet to make his ODI debut and his call-up comes after scoring 400 runs in this season's domestic one-day competition, the Momentum One Day Cup.
That haul of runs has included four half-centuries and a top score of 95 in nine games.
"Henry has performed for us in the T20 format and this is another opportunity for him to make a contribution in the ODI squad," Cricket South Africa (CSA) Selection Convenor Andrew Hudso said.
"He had a successful run in the Momentum One-Day Cup and this is just reward for his consistent performances."
Pakistan have already sealed the series with victories in the first two matches in Cape Town and Port Elizabeth and South Africa will also be missing Jacques Kallis and Dale Steyn with finger and side strain injuries respectively.
South Africa ODI squad: AB de Villiers (captain), Hashim Amla, Henry Davids, Quinton de Kock, JP Duminy, Imran Tahir, Ryan McLaren, David Miller, Morne Morkel, Wayne Parnell, Vernon Philander, Lonwabo Tsotsobe
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