Australia captain Michael Clarke has been ruled out of the opening One-Day International tri-series match against Zimbabwe due to a hamstring injury.
Clarke was always struggling to be fit for the opening match in Harare tomorrow (25th August) and has failed a fitness test.
Off-spinner Nathan Lyon will make his first ODI appearance since 2012 and Hughes is the nominated 12th man.
"Michael had a fitness test at training today and unfortunately hasn't come through that well enough to be available for selection in game one," coach Darren Lehmann confirmed.
"He will continue intensive treatment on his hamstring and we'll monitor his progress ahead of game two on Wednesday.
"Looking at the wicket today, we've opted to go with the spin option of Nathan Lyon along with the extra all-rounder to add further depth to our batting line-up which means that Phil Hughes has unfortunately missed out on selection."
Australia play both South Africa and Zimbabwe twice in the tri-series, which concludes with the final on 6th September.
Australia: George Bailey (captain), Aaron Finch, James Faulkner, Brad Haddin, Mitchell Johnson, Nathan Lyon, Mitchell Marsh, Glenn Maxwell, Kane Richardson, Steve Smith, Mitchell Starc.
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