According to a statement from the Pakistan Cricket Board, Irfan suffered cramps in his hamstring but they later spread to his calves and hence he is being sent back home to improve his fitness.
Irfan bowled a five-over spell at the start and accounted for both the England openers but had to spend time off the field.
When he returned in the 42nd over in an attempt to bowl a second spell, he managed to bowl just one wide and walked off the field.
Pakistan bowling coach Azhar Mahmood said that though the team management was unhappy with Irfan’s fitness, he acknowledged that the height of the 34-year-old posed a unique set of challenges.
“Definitely Mickey was unhappy and as bowling coach I was unhappy as well. We had a chance to win that game the other day,” Mahmood said.
“Unfortunately, everyone gets cramp. He is a big guy and his body is totally different to a normal human. But he got cramps.”
The Pakistan selectors have drafted fast bowler Hasan Ali to replace Irfan in the squad for the lone Twenty20 International to be played at Old Trafford on 7th September.
© Cricket World 2016