With the series already in the bag, South Africa will rest Hashim Amla from the third One-Day International against Zimbabwe in Bulawayo.
The opening batsman will return home to South Africa before travelling back to Zimbabwe in time for the ODI tri-series that also includes Australia.
His absence means that Rilee Rossouw can expect to make his international debut in the third game on Thursday (21st August).
South Africa may also look to give Mthokozisi Shezi and Marchant de Lange an opportunity after neither player featured in the first two games.
South Africa won Tuesday's game by dismissing Zimbabwe for 196 after they had been bowled out for 257, but captain AB de Villiers said he was satisfied with his side's overall batting effort.
"It wasn't a bad batting performance considering that our top order didn't score a lot of runs," he sai.
"The fact that Parney (Parnell) and some of the middle order and tail chipped in a lot was pleasing to me; its shows that there is a lot of depth in the batting order.
Looking ahead to the final game, he revealed that South Africa will make changes.
"There will possibly be two or three changes. The most important one to mention is Hashim.
"He has played a lot of cricket and scored a lot of runs, so it will be a good opportunity for him to take some time off for one game and get him back here for the tri-series nice and fresh.
Asked about the players who will come in to the side, de Villiers added that he had no concerns.
"They have played a lot of cricket of late and they are all in decent form.
"I don't want to put too much pressure on them, I want to free them up and allow them to express their talent if they get an opportunity.
"There are still rankings at stake, so as a team we would like to win even though we might make a few changes."
© Cricket World 2014