Left-arm seamers Wayne Parnell and Lonwabo Tsotsobe will both make their ODI debuts for South Africa in the fifth and final match against Australia in Perth on Friday (January 30th).
Vaughn van Jaarsveld, if he recovers from an ankle sprain, is also set to play as the South Africans are to field their youngest playing XI ever having wrapped up the series with an eight-wicket win in Adelaide.
Tsotsobe will make his debut at the same venue where his mentor Makhaya Ntini started his career 1998.
“I don't know which of the two of us is more excited,” Ntini said.
“I have told Lopsy (as he is known to his team mates) that this is the place where it all started for me,” he added. “I still remember having Craig McMillan caught by Jonty Rhodes at point and then I got Stephen Fleming as well. I can't remember who my third wicket was.
“This is where he must make his mark. He must put down a big box and put all his eggs into it.”
Parnell's inclusion means that South Africa will play with two left-arm fast bowlers in a match for the first time since readmission.
Australia have vice-captain Michael Clarke and experienced fast bowler Nathan Bracken available for selection after injury.
South Africa (possible): Hashim Amla, Herschelle Gibbs, Jacques Kallis, JP Duminy, AB de Villiers, Vaughn van Jaarsveld, Johan Botha, Albie Morkel, Morne Morkel, Wayne Parnell, Lonwabo Tsotsobe