Nottinghamshire batsman James Taylor will reprise his role as England Lions captain when they meet the touring West Indies in a four-day game at Northampton.
Taylor led the Lions side against the touring Sri Lanka A team in 2011 and in Bangladesh, Sri Lanka and the United Arab Emirates this winter.
He is joined in the squad by a number of players with international experience and others who have made good starts to the English domestic season, for the game which begins on 10th May.
Jonathan Bairstow, Michael Carberry, Jade Dernbach, Stuart Meaker, Samit Patel and Ben Stokes are the players in the squad who have been capped by England.
Jack Brooks, Matt Coles, Nick Compton, Simon Kerrigan and Joe Root are the other names in the squad.
Nine of the 12 players toured with the Lions over the winter - Carberry, Compton and Stokes being added while Coles is the only player lacking any experience of either playing for the Lions or the full international team.
"Many of the players included in this squad have worked hard on our overseas tours and training camps over the winter or have shown good early season form," National Selector Geoff Miller said.
"West Indies will no doubt be challenging opposition and this fixture will present an opportunity for players to show that they are capable of taking the next step and representing England at Test level in the future," he added.
England Lions: James Taylor (captain), Jonathan Bairstow, Jack Brooks, Michael Carberry, Matt Coles, Nick Compton, Jade Dernbach, Simon Kerrigan, Stuart Meaker, Samit Patel, Joe Root, Ben Stokes
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