Cheteshwar Pujara scored a crucial half-century to take the Indian lead to 142 with eight wickets in hand after the spinners led by Ravichandran Ashwin tormented South African batting line-up in day two of the first Test in Mohali.
12 wickets fell on a dramatic first day of the first Test in Mohali where India fought back with two South African wickets after Dean Elgar's four-wicket haul skittled Virat Kohli's men out for just 201 runs earlier in the day.
An overwhelmingly powerful all-round performance from South Africa trounced India by 214 runs in the fifth One-Day International in Mumbai, handing them their maiden bilateral series victory against the hosts in India.
Indian spinners spun a web around the South African batsmen after a magnificent century by Virat Kohli to win the fourth One-Day International series by 35 runs in Chennai, thereby levelling the series.
Riding on the back of a composed century from Quinton de Kock and a four-wicket haul from Morne Morkel, South Africa defeated India in the third One-Day International in Rajkot to take a 2-1 lead in the five-match series.