South African cricketers, Morne Morkel and JP Duminy are set to make a return after recovering from their injuries while fast bowler Dale Steyn is doubtful for the second Test against India in Bangalore.
Ravindra Jadeja and Ravichandran Ashwin shared eight wickets between them as India made full use of a dry Mohali pitch to dismiss South Africa for 109 in their final innings and secure a 108-run victory in the first Test.
Cheteshwar Pujara scored a crucial half-century to take the Indian lead to 142 with eight wickets in hand after the spinners led by Ravichandran Ashwin tormented South African batting line-up in day two of the first Test in Mohali.
12 wickets fell on a dramatic first day of the first Test in Mohali where India fought back with two South African wickets after Dean Elgar's four-wicket haul skittled Virat Kohli's men out for just 201 runs earlier in the day.
An overwhelmingly powerful all-round performance from South Africa trounced India by 214 runs in the fifth One-Day International in Mumbai, handing them their maiden bilateral series victory against the hosts in India.
Indian spinners spun a web around the South African batsmen after a magnificent century by Virat Kohli to win the fourth One-Day International series by 35 runs in Chennai, thereby levelling the series.
Riding on the back of a composed century from Quinton de Kock and a four-wicket haul from Morne Morkel, South Africa defeated India in the third One-Day International in Rajkot to take a 2-1 lead in the five-match series.