Ashan Priyanjan Replaces Jayawardene
He has asked to miss the match due to personal reasons and has been given permission to do so by Sri Lanka Cricket.
Priyanjan, who led Sri Lanka A when they played England in a tour game last month, comes into the squad as his replacement.
He has played 21 One-Day Internationals for his country including the first three matches of Sri Lanka's recent 5-0 defeat in India.
Sri Lanka lead the seven-match series 2-0 after wins at the R Premadesa Stadium in Colombo.
The series returns to Colombo for the fourth match before Pallekele hosts the fifth and sixth matches while the RPS will be in action again for the series' conclusion.
Sri Lanka squad for 3rd ODI: Angelo Mathews (captain), Tillakaratne Dilshan, Shaminda Eranga, Lahiru Gamage, Rangana Herath, Thilina Kandamby, Ajantha Mendis, Jeevan Mendis, Dilruwan Perera, Kusal Perera, Thisara Perera, Dhammika Prasad, Kumar Sangakkara, Lahiru Thirimanne
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