Chronic ankle injury ends Mark Wood's UAE tour
The injury had earlier forced him to miss the third Ashes Test at Edgbaston as well.
The 25-year-old had a cortisone injection this week following which the team management had decided to rest him for the remainder of the United Arab Emirates tour.
England have Steven Finn and Chris Jordan as a possible replacement for Wood in the third Test while the left-arm spinning all-rounder Samit Patel will also be in contention.
Meanwhile, England are also mulling to drop out-of-form wicket-keeper batsman, Jos Buttler for the third Test.
Buttler has been in horrible form having scored only 34 runs in the two Tests in UAE.
His form in the 2015 Ashes series too wasn't encouraging either as he managed only 122 runs in the five games at an average of 15.25.
In case of Buttler being dropped, middle order batsman, James Taylor is likely to return to the line-up after three years while Jonny Bairstow will don the gloves.
England all-rounder Ben Stokes stated that time off from the game can help Buttler regain his touch in case he misses out on the third game.
"If the decision comes to leave Jos out, then he is not a bloke to dwell on it too much," Stokes said.
"He will go away and work as hard as he always does on all aspects of his game from batting to keeping.
"I've been in the same position as he has before, and it's not a nice place to be, but everything comes around and eventually you do find form.
"You've just got to keep working hard in practice.
"If it does end up with him not playing then the time off might do him some well because he's had a very, very long summer."
Having lost the second Test, England are in a must win situation when they face Pakistan in Sharjah for the third Test on 1st November.
© Cricket World 2015