Pettman, who has taken 38 first-class wickets at an average of 22.71, previously featured for Derbyshire in their victory over Middlesex at Queen’s Park, Chesterfield, claiming 3-40 in the first innings.
He will join the squad to travel to the Seat Unique Riverside for the fixture starting on Monday 11 July, as Derbyshire look to build on their two red ball wins so far.
Head of Cricket, Mickey Arthur, said: “Due to the intense nature of the fixture schedule, and a few knocks and niggles within our seam bowling department, we felt it was necessary to bring Toby back in and get some fresh energy into the attack.
“Toby really impressed us against Middlesex, and he will have another big opportunity against Durham to showcase his ability in first-class cricket.”
Pettman added: “I really enjoyed my first stint with Derbyshire, it’s a great group of players and I’m excited to join-up with the squad again for the Durham fixture.
“It’s another chance for me to gain experience against a top opposition, hopefully I can help Derbyshire to what would be another important win.”