India Rest Ashwin, Recall Mishra
Karn Sharma, the other specialist spinner that played in India's 3-1 series win over England earlier this year, is left out, along with all-rounder Stuart Binny, fast bowler Dhawal Kulkarni and batsman/wicket-keeper Sanju Samson.
With Rohit Sharma still unavailable due to the finger injury he suffered in England, Murali Vijay retains his place in the squad.
Kuldeep, who plays for Kolkata Knight Riders and Uttar Pradesh, is uncapped and has played just eight Twenty20 matches in his career to date.
Mishra's last ODI came against Bangladesh in June, a game in which Akshar Patel, another spinner also played.
He, along with Robin Uthappa and Cheteshwar Pujara, who toured Bangladesh when a number of senior players were rested, has been left out of this squad.
The five-match series begins with the first ODI in Kochi on Wednesday 8th October.
India ODI squad: MS Dhoni (captain), Shikhar Dhawan, Ravindra Jadeja, Virat Kohli, Bhuvneshewar Kumar, Amit Mishra, Mohammad Shami, Mohit Sharma, Suresh Raina, Ajinkya Rahane, Ambati Rayudu, Muarali Vijay, Kuldeep Yadav, Umesh Yadav
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